中创房地产是有分量的

科学网喝酒致癌再添新“铁证”?

2017-06-26 16:30栏目:通信

喝酒究竟能不能致癌?这是一个问题;喝酒究竟有益还是有害?这又是另一个问题。对于后一个问题,相信大家的看法比较一致:适量饮酒有益健康,过量饮酒(酗酒)有害健康。可是,对于前一个问题,众说纷纭,不成定论。

目前有关喝酒与致癌的相关性研究很多,各种流行病学分析大数据可以信手拈来,以下随便举两个最新的例子,均来自两篇今年刚发表的文章。

喝酒与前列腺癌和肺癌发生率成负相关


2017 Apr 18. doi: 10.1038/pcan.2017.12. [Epub ahead of print]

Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case-control study.

Abstract

BACKGROUND:

Ethanol in alcoholic beverages is a known carcinogen, but its association with aggressive prostate cancer (APC) is uncertain. Recent studies have shown a modest increase in risk of APC associated with heavy alcohol intake while association for beverage types remain inconsistent.

METHODS:

Using a case-control design and self-administered questionnaire, we examined the association between APC (high grade and/or advanced stage) and frequency and quantity of alcohol intake 2 years prior to enrolment. Furthermore, we delineated the relationships for beverage-specific intakes of beer, red wine, white wine and spirits.

RESULTS:

The study included 1282 APC cases and 951 controls. Beer intake frequency of ⩾5 days per week was associated with increased risk compared with no beer intake (odds ratio=1.66, 95% confidence interval: 1.12-2.48) whereas wine was protective at all frequencies of consumption compared with those with no wine intake. For every 10 g per week ethanol intake from beer increase, the odds of advanced PC rose by 3% (OR=1.03, 95% CI: 1.02-1.05). No such increased risk was observed for red or white wine while a marginal dose-response relationship was found for spirits (OR=1.03, 95% CI: 0.99-1.07).

CONCLUSIONS:

Heavy beer and possibly spirits consumption is associated with increased risk while no dose-response relationship was found for red or white wine. Wine drinkers at all frequencies have a decreased risk of APC compared with those who did not drink wine. Prostate Cancer and Prostatic Diseases advance online publication, 18 April 2017; doi:10.1038/pcan.2017.12.


这篇是喝酒与前列腺癌的相关性研究结论:狂饮啤酒(每周5天以上)可提高前列腺癌风险(OR=1.66),而白或红葡萄酒无论喝多少都能防止前列腺癌的发生。至于烈性酒,致癌率仅略有升高(OR=1.03)。

2017 May 1;140(9):1976-1984. doi: 10.1002/ijc.30618. Epub  2017 Feb 27.

Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study.

Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.

这篇是喝酒与肺癌的相关性研究结论:喝酒与罹患肺癌的风险成负相关,尤其是低度至中度饮用葡萄酒或白酒,但不包括喝啤酒。