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成年听觉皮层神经元周围的“栅栏”为恐惧学习记忆所必需

2017-07-14 16:58栏目:评测
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Neuron——成年听觉皮层神经元周围的“栅栏”为恐惧学习记忆所必需


Summary

1.Muscimol-Mediated Inactivation of Auditory Cortex before Auditory Fear Conditioning Decreased Fear expression Observed 24 and 48 hr Later


2.Muscimol-Mediated Inactivation of Auditory Cortex after Auditory Fear Conditioning Decreased Fear Expression Observed 24 and 48 hr Later


3.mRNA Levels of Genes Encoding Lecticans Were Enhanced 4 hr after Fear Conditioning but Returned to Baseline Levels 24 hr Later


4.PNN Expression Was Specifically Enhanced 4 hr after Tone-Shock-Paired Fear Conditioning but Returned to Baseline Levels 24 hr Later


5.Removal of PNNs in the Auditory Cortex Using ChABC before Auditory Fear Conditioning Decreased Fear Expression Observed 24 and 48 hr Later but Did Not Decrease Fear Expression 30 min Later


6.Removal of PNNs in the Auditory Cortex after Fear Conditioning Results in Decreased Fear Expression Observed after 24 and 48 hr,but Not 30 min after Fear Conditioning

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成年听觉皮层神经元周围的“栅栏”为恐惧学习记忆所必需