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CoA合成酶调节组蛋乙酰化和海马学习记忆能力

2017-07-14 16:59栏目:评测
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Nature——Acetyl-CoA合成酶调节组蛋乙酰化和海马学习记忆能力


Summary


1.Nuclear ACSS2 supports neuronal gene expression.


2.ACSS2 is recruited to transcriptionally active chromatin
and promotes neuronal histone acetylation.


3.ACSS2 ChIP–seq localization is linked to histone acetylation in vivo in mouse hippocampus.


4.ACSS2 knockdown in dorsal hippocampus impairs object
location memory and upregulation of immediate early genes following training.

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CoA合成酶调节组蛋乙酰化和海马学习记忆能力